Electroporation: The Most Deeply Penetrating Needless Alternative!

Electroporation Technology:
Trans-dermal Delivery System of Mesotherapy Serums, Skin Care Products, Homeopathy, and More

 

     The device employs clinically proven Electroporation and Electro-osmosis techniques which temporarily alter the cells’ plasmatic membrane permeability,
causing the opening of recently discovered intracellular channels. This enables the introduction of active principles via the electroporation unit. The effect of electroporation was first described in the 1960s and was perfected for cellular gene transfer, drug infusion and cancer research in the 1980s.
Electroporation operates by applying pulsed, modulated, non thermal and non-ionized electromagnetic waves (EMW) of hectometric frequency, produced by a low amplitude of intensely alternating current within an application wand. These EMWs produce an alteration of the cellular membrane temporarily.
This alteration provokes a biological “moment” with an electro- rotation of lipids in the phospholipids’ bi-layer of the cell membrane, causing formation & activation of aquaporins (AQP or specifically aquaglyceroporins ) or water channels — integral water membrane transport proteins discovered in 1992 by a Nobel prize winner in chemistry, Dr. Peter Agre, MD of Johns Hopkins University, which he shares with Roderick MacKinnon,  professor of Molecular Neurobiology and Biophysics at Rockefeller University for their discovery of aquaporins [1].  Aquaporins are water-channel proteins that move water molecules through the cell membrane. The momentary opening of these protein channels enables substances to enter the cells. Electroporation is routinely used in cancer research and drug delivery.
     Electroporation is reversible and temporary because the applied current is pulsed and not constant. The cells return to their normal state once the impulse discharge is stopped. It has an ON/OFF mechanism with no cellular damage.
With the unique natural and homeopathic protocols and equipment, the Electroporator transports hydrophilic solution molecules most effectively through the skin’s stratus corneum barrier. Highly effective nutritional, cell building and pain management components are then infused directly into the cells of a uncontrollably chosen depth. You can deliver solutions directly into cells in order to treat most kinds of skin conditions faster and more effectively. The technology further promotes skin metabolism, and enhances skin elasticity. Studies indicate that Electroporation is 500X more effective than other trans-dermal delivery methods such as iontophoresis (micro-currents) or ultrasound. It works with ionized and neutral substances alike.
1 Agre P (2006). "The aquaporin water channels". Proc Am Thorac Soc 3 (1): 5–13. doi:10.1513/pats.200510-109JH. PMC 2658677.

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Micro Currents: A Needle-less Alternative with Great Tissue Lifting and Toning Potential

Micro current therapy, commonly referred to as MENS (Micro current Electrical Neuromuscular Stimulation), is extremely small pulsating currents of electricity.

These currents are finely tuned to the level of the normal electrical exchanges which take place at body’s cellular level. These currents being more biologically compatible

than any other electrical stimulation device, have the ability to penetrate the cell - as opposed to passing over the cell as other stimulation devices do. It works on

ARNDT - SCHULTZ Law which states that : “Weak stimuli increases physiological activity and very strong stimuli inhibit or abolish activity.”

This subsensory current normalizes the ordinary activity taking place within the cell if it has been injured or otherwise compromised. 

The external addition of micro current will increase the production of ATP, protein synthesis, oxygenation, ion exchange, absorption of nutrients, elimination of waste

products, and neutralizes the oscillating polarity of deficient cells. Homeostasis is restored. 

The biologically sensitive stimulation effect of micro current picks up where the body’s own electrical current fails, as the human body must adhere to the natural law

of electricity which is : “ electricity must take path of least resistance.”. Therefore, its electrical current is destined to move around an injury or defect, rather than through it. 

By normalizing cell activity, inflammation is reduced while collagen producing cells are  increased. Healthy cell metabolism creates a healthy, pain free internal environment. 

DOUBLE - BLIND STUDIES LERNER AND KIRSCH, on chronic and acute back pain show the overwhelming effect of MENS over other modalities. 

Internal exchanges within the body have been long understood by medical practitioners. Applying that knowledge has been slow in developing. Doctors and physical therapists all over the world have been using micro current to heal injured muscles, tendons, wounds and a myriad of injuries and ailments for the past fifteen years.

Summary

The MENS unit is biologically more compatible with the body’s own electrical system. It is more effective in neutralizing the oscillating polarity of injured cells. Micro Currents

have a positive effect of increasing the availability of ATP, increasing cell permeability, making nutrient transport of waste more efficient, increasing protein synthesis and ion

exchange.

The dual tipped probes, as opposed to single tipped probes, offer mixed frequency with unmatched waveforms creating the crisscrossed pattern of four current emission streams instead of one. This increases the tissue saturation without increasing current to maintain the ultimate healing aspect of low frequency. There are thirty two preprogrammed treatments with the ability to customize your own programs for special situations. The preprogrammed treatments are diverse enough to cover most situations encountered. However, for the purpose of research, or a particularly stubborn case, the ability to set custom programs is essential.

Methods of Application:

Moistened cotton swabs on probe tips are particularly useful in lengthening or shortening muscles and tendons, wound healing, rejuvenating skin, facelifts, body toning,

organ enhancement etc. 

Pads for unattended treatments and pain relief, or over saline saturate gauze on decubiti and wounds. 

Gloves for massage or covering a larger surface area. 

Pads in water for whole body treatment such as : increased circulation, reduced stress, increased intestinal peristalsis, energy, reduced hemorrhoids, gastric symptoms,

and many other problems. 

Physical therapists, always on the lookout for the better equipment, have been among the first in the medical profession to realize the potential for the MENS equipment.

Doctors, concerned about the overuse of pharmaceuticals and more invasive procedures, are having office personnel trained to use the equipment to reduce costs to patients.

Insurance companies recognize and will pay for the therapy. It helps bring back the personal touch to the healing profession. 

Electricity

Electricity is usually measured in amperes. Micro amps used in micro current therapy are one millionth of an ampere or one thousandth of a milliampere. It would take one million micro current machines to light a 40 watt light bulb. This is mentioned in an effort to emphasize the minuteness of the electrical currents used in micro currents therapy. These small, therapeutic doses augment the body’s own healing ability with no discomfort to the patient. It eliminates overdoses, over stimulation, misuse, and side effects. It removes much of anxiety of medical misjudgements and guesswork while offering unlimited creative and healing potential.

A brief reminder : Muscle Contraction Physiology

Let’s us start with a brief reminder of muscle physiology. Skeletal muscles are a composition of fibres innervated by nerves. Nerve impulses pass through a neuromuscular junction into the muscle fibre. The nerve impulses, or current, continue through the muscle fibre to stimulate the “action potential”, triggering a large release of calcium. This initiates the contraction process. The contraction continues as the muscle cell’s increased permeability allows sodium ions to enter the cell, and the intracellular negativity is reinstated. 

Energy for this process to occur, comes from the nucleotide compound ATP ( Adenosine Triphosphate ) being reduced to ADP ( Adenosine Diphosphate ). Large amounts of ATP are used up during a contraction and must constantly be replenished. ATP is derived from metabolism of carbohydrates, fats, proteins and oxygen - nutrition. 

When a muscle is traumatized, it protects itself by going into spasm. This decreases blood supply, nutrients, oxygen and ATP, disrupts the sodium pump, and increases waste products within the cell. The electrical current of injured tissue takes on positive charge differing from the negative charge of healthy tissue. Non injured cells try to restore normal electrical function, but the body’s electrical system is subject to the natural law of electricity which dictates : “electricity must take the path of least resistance.” and travels around the injured tissue.

Normalizing Damaged Tissue

With the addition of external micro stimulation, the damaged tissue recovery period is dramatically reduced.

Tissue pathology begins with injured or otherwise insulted cells that exude certain biochemical substances, such as arachidonic acid, from the lipid portion of the cell membrane into their interstitial environment. These substances are responsible for turning on a complex array of inflammatory and pain - producing responses. The best way to accelerate relief from these responses is to accelerate the intracellular processes that result in the repair or replacement of the injured cells themselves. This involves accelerating the production of ATP 
(primary conveyor of energy within the cell), new protein and new DNA, if new cells are required. The calcium concentration within the cells is known to play a very important role in activating a variety of enzymes which turn on the above processes. It has been shown that passing electrical current across the membrane of tissue cells (such as fibroblasts, which form new tissue in healing wound) in an optimal fashion will do remarkably effective job of opening certain membrane channels to calcium ions. Calcium ions will then proceed to enter the cell from interstitial fluid (where they are more concentrated), and increase their concentration within the cell.

Electrical stimulation of a tissue also results in improved circulation by several mechanisms, which may include the local release of vasodilator substances and decrease in sympathetic vasoconstrictor reflex activity. This can result in :

1. Reduced pain at injury site
2. Improved neuromuscular responsiveness
3. Reduction of inflammatory responses
4. Increased range of motion and reduction of tightness in disturbed muscle tissue
5. Reduced recuperation time and less neuromuscular inhibition leading to enhanced contractility of muscle fibres.

ATP

Glucose, upon entering the cell is immediately phosphorized by ATP in the presence of hexokinase and Mg ++. The cell must have a stored reserve of ATP for energy consumption.

The following is only intended to highlight the great importance of ATP < - > ADP + P + reaction for cell life : One mole of glucose metabolized via tricarboxylic  (TCA) cycle or “Krebs cycles” yields a 38 moles of ATP. One mole of glucose metabolized via the anaerobic glycolysis (The Emboden - Myerhof Cycle) yields 2 moles of ATP. 

ATP is the highest energy producing substance for the cell, and is immediately available for the complex endergonic processes of the cells, as established by the genetic code and the RNA (Ribonucleic Acid) structure. 

A study by Cheng et al, 1982, using micro current accelerated ATP generation, protein synthesis, and membrane transport gives an in - depth report. Results on rat skin showed ATP generation increased 500%. Amino acid transport increased 30 - 40%. 

Nociceptive fibres., free nerve endings sensitive to tissue dysfunction, are found in skin, fibrous capsule, periosteum, intra muscular arteries, blood vessels walls and, in abundance, in the blood vessels walls and, in abundance, blood vessels of adipose tissue. These fibres send pain impulses to the brain.

Retonification of the Muscle

The initial phase of treatment to normalize the cell is followed by returning the muscle to its normal shape and position. 

By stimulating the efferent fibres at the origin and insertion points of the involved muscle or muscles, the muscle can gently be coaxed into being stretched or shortened with no pain to the patient. An atrophied muscle can be shortened and toned. A muscle in spasm can be stretched. Anti - inflammatory and pain reducing drugs are either eliminated or drastically reduced.

Chronic Pain

Acute pain is alleviated quickly and chronic pain, with a bit more persistence, is greatly affected with the use of micro current therapy. There is no greater sense of satisfaction than watching a twenty year old injury heal after years of suffering by the patient. No one understands pain better than someone who’s been told they must “learn to live with it”. After having lived with it, to have it removed is the greatest kindness one can bestow on another. 

A study by Mayo clinic found 24% of chronic pain sufferers to be drug dependent and 42% to be abusers. Between $ 33,000,000 and $ 50,000,000 a year, are spent on medication. Chronic pain is, indeed, a major health problem.

Current Uses

Although it has been primarily used in sports medicine with thigh - clapping enthusiasm from the athletes themselves, sports medicine is only the beginning. It has been widely used in : 

wound healing	arthritis	intractable pain	whiplash	TMJ syndrome
pre-op surgery	disc disease	torticollis	post operative healing	sinus problems
migraines	stroke rehab	soft tissue	injury	acute pain
capsulitis	tendonitis	Bell’s palsy	myofacial pain	decubitus
synovitis	bursitis	surgical incision	chronic pain	myositis
neuropathies	carpal tunnel	abdominal cramps	oedema

Studies are being done in various parts of the world using micro current to help sleep disorders, drug and alcohol rehabilitation, stress, depression, cancer, chronic fatigue, spinal cord injury rehabilitation, and even AIDS.

Decubitus

Decubitus, an indolent skin ulcer, which is the bane of the medical profession, causes great amounts of lost time and wages for the patient.



Ulcers in these patients were chronic and showed little or no improvement in the previous 13 weeks of therapies. In various studies it was noticed that collagen producing cells increased during treatment.

Research on body Electrical Systems

Robert O. Becker, M.D., reports that naturally occurring electric currents are measurable in the body, which send electrical signals through the Schwann and glial cell sheaths surrounding neurons to an area of injury. This process triggers the repair and regeneration process. he found that the human body is normally polarized  positively along the central spinal axis and negatively peripherally. 

Bjorn Nordenstrom, M.D., author of Biologically Closed Electric Circuits : Clinical, Experimental and Theoretical Evidence for an Additional Circulatory System, states that bioelectricity is conducted through the micro capillary circulatory system in the body. When injury occurs, a positive charge builds up in the area of injury and sets up the voltage potential difference which serves as biological battery waiting for the switch to be turned on. The bioelectricity is then switched on by a change in the electrical insulation properties of the capillary membranes. As they become less permeable to the flow of ions and become more electrically insulated, the bio electric flow of energy is forced to take path of least resistance, which is through the bloodstream. Thus the bio electric switch is through the bloodstream.